| How degrading: The role of protein turnover and autophagy in agingAs cells age, detritus inevitably accumulates; one theory of aging holds that rising levels of unwanted molecules will eventually become cytotoxic; this, in turn, could cause age-related decline in tissue function. Cells have a variety of means to eliminate misfolded, damaged and covalently altered proteins; here is a review of some recent articles on the role of these mechanisms in aging -- including one idea about how this knowledge might be incorporated into life extension technology. |
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