| Telomerase RNA alone can extend cellular lifespan - but is there a tradeoff?Mounting evidence now indicates that impaired telomerase activity impacts the stem/progenitor compartment, resulting in premature exhaustion of the haemopoietic progenitors, and reduced number of peripheral blood progenitor cells. Mutations in the various subunits of the telomerase complex have been reported, with the RNA subunit, TERC, shown to be the limiting factor for telomerase activity and telomere length in dyskeratosis congenia patient fibroblast strains. |
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